Structure of PDB 5ltm Chain B

Receptor sequence
>5ltmB (length=537) Species: 1163 (Anabaena) [Search protein sequence]
NVIIGNQKLTINDVARVARNGTLVSLTNNTDILQGIQASCDYINNAVESG
EPIFGVTSGFGGMANVAISREQASELQTNLVWFLKTGAGNKLPLADVRAA
MLLRANSHMRGASGIRLELIKRMEIFLNAGVTPYVYEFGSIGADLVPLSY
ITGSLIGLDPSFKVDFNGKEMDAPTALRQLNLSPLTLLPKEGLAMMNGTS
VMTGIAANCVYDTQILTAIAMGVHALDIQALNGTNQSFHPFIHNSKPHPG
QLWAADQMISLLANSQLVRDELDGKHDYRDHELIQDRYSLRCLPQYLGPI
VDGISQIAKQIEIEINSVTDNPLIDVDNQASYHGGNFLGQYVGMGMDHLR
YYIGLLAKHLDVQIALLASPEFSNGLPPSLLGNRERKVNMGLKGLQICGN
SIMPLLTFYGNSIADRFPTHAEQFNQNINSQGYTSATLARRSVDIFQNYV
AIALMFGVQAVDLRTYKKTGHYDARASLSPATERLYSAVRHVVGQKPTSD
RPYIWNDNEQGLDEHIARISADIAAGGVIVQAVQDIL
3D structure
PDB5ltm Zymophore identification enables the discovery of novel phenylalanine ammonia lyase enzymes.
ChainB
Resolution2.413 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) F78 G85 L108 N223 Y314 R317 F363 Q452
Catalytic site (residue number reindexed from 1) F54 G61 L84 N197 Y288 R291 F337 Q426
Enzyme Commision number 4.3.1.24: phenylalanine ammonia-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HCI B Y314 R317 Y288 R291
BS02 HCI B F84 X168 L171 F60 X143 L145
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004397 histidine ammonia-lyase activity
GO:0016829 lyase activity
GO:0016841 ammonia-lyase activity
GO:0045548 phenylalanine ammonia-lyase activity
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0009072 aromatic amino acid metabolic process
GO:0009698 phenylpropanoid metabolic process
GO:0009699 phenylpropanoid biosynthetic process
GO:0009800 cinnamic acid biosynthetic process
GO:0044550 secondary metabolite biosynthetic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ltm, PDBe:5ltm, PDBj:5ltm
PDBsum5ltm
PubMed29057979
UniProtQ3M5Z3|PAL_TRIV2 Phenylalanine ammonia-lyase (Gene Name=Ava_3988)

[Back to BioLiP]