Structure of PDB 5lpm Chain B

Receptor sequence
>5lpmB (length=116) Species: 9606 (Homo sapiens) [Search protein sequence]
SMIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKS
PMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKL
SEVFEQEIDPVMQSLG
3D structure
PDB5lpm Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
ChainB
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 71Y B W1115 W1122 E1150 W70 W77 E105 MOAD: Kd=2.77uM
BS02 71Y B P1074 V1079 Y1131 N1132 P29 V34 Y86 N87 MOAD: Kd=2.77uM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5lpm, PDBe:5lpm, PDBj:5lpm
PDBsum5lpm
PubMed28766825
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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