Structure of PDB 5loh Chain B

Receptor sequence
>5lohB (length=250) Species: 9606 (Homo sapiens) [Search protein sequence]
PSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKALSKSPF
IVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVAL
ALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLGTPDYLAPELLLGRA
HGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKL
SDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQP
3D structure
PDB5loh A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.
ChainB
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D156 K158 D160 N161 D174 T741
Catalytic site (residue number reindexed from 1) D114 K116 D118 N119 D132 T137
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU B I41 S42 A60 K62 M110 E111 Y112 L113 G116 D117 D160 N161 L163 T173 L177 I12 S13 A31 K33 M68 E69 Y70 L71 G74 D75 D118 N119 L121 T131 L135
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5loh, PDBe:5loh, PDBj:5loh
PDBsum5loh
PubMed27563826
UniProtQ96GX5|GWL_HUMAN Serine/threonine-protein kinase greatwall (Gene Name=MASTL)

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