Structure of PDB 5li3 Chain B

Receptor sequence
>5li3B (length=368) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
RRTAFFFDELCLWHAAGPHALTLPVGGWVQPPAAAGHAESPETKRRLKSL
LDVSGLTARLQLRSAPPASDEDLLRVHPAHYLERFKALSDAGGGSLGQDA
PIGPGSYEIARLSAGLAIAALDAVLAGEADNAYSLSRPPGHHCLPDQAMG
FCFFANIAVAIEAAKARHGVERVAVLDWDVHHGNGTQAIYYRRDDVLSIS
LHQDGCFPPGYSGAEDIGEDRGRGFNLNVPLLPGGGHDAYMQAMQRIVLP
ALERFRPQLIVVASGFDANAVDPLARMQLHSDSFRAMTAMVRDAAERHAG
GRLVVVHEGGYSEAYVPFCGLAVIEELSGVRSAVRDPLRDFIELQQPNAA
FRDFQRQRLEELAAQFGL
3D structure
PDB5li3 Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors.
ChainB
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9RB B L340 F343 L338 F341 MOAD: ic50=0.053uM
PDBbind-CN: -logKd/Ki=7.28,IC50=0.053uM
BS02 ZN B D181 H183 D269 D179 H181 D267
BS03 9RB B T24 D101 H144 F153 D181 H183 F209 D269 Y313 T22 D99 H142 F151 D179 H181 F207 D267 Y311 MOAD: ic50=0.053uM
PDBbind-CN: -logKd/Ki=7.28,IC50=0.053uM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0040029 epigenetic regulation of gene expression

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Molecular Function
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Biological Process
External links
PDB RCSB:5li3, PDBe:5li3, PDBj:5li3
PDBsum5li3
PubMed27756124
UniProtQ9HXM1|HDAH_PSEAE Histone deacetylase-like amidohydrolase (Gene Name=PA3774)

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