Structure of PDB 5lgp Chain B

Receptor sequence

>5lgpB (length=343) Species: 10090 (Mus musculus) [Search protein sequence]

RSVFSERTEESSAVQYFQFYGYLSQQQNMMQDYVRTGTYQRAILQNHTDF
KDKIVLDVGCGSGILSFFAAQAGARKIYAVEASTMAQHAEVLVKSNNLTD
RIVVIPGKVEEVSLPEQVDIIISEPMGYMLFNERMLESYLHAKKYLKPSG
NMFPTIGDVHLAPFTDEQLYMEQFTKANFWYQPSFHGVDLSALRGAAVDE
YFRQPVVDTFDIRILMAKSVKYTVNFLEAKEGDLHRIEIPFKFHMLHSGL
VHGLAFWFDVAFIGSIMTVWLSTAPTEPLTHWYQVRCLFQSPLFAKAGDT
LSGTCLLIANKRQSYDISIVAQVDQTGSKSSNLLDLKNPFFRY

3D structure

PDB

5lgp Transition state mimics are valuable mechanistic probes for structural studies with the arginine methyltransferase CARM1.

Chain

Resolution

2.04 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D166 E258 E267 H415
Catalytic site (residue number reindexed from 1)	D32 E124 E133 H281
Enzyme Commision number	2.1.1.319: type I protein arginine methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	Q149 Y150 F153 Y154 N162 M163 E258 Y262 E267 K310 H415 Y417 F475 Y477	Q15 Y16 F19 Y20 N28 M29 E124 Y128 E133 K176 H281 Y283 F341 Y343
BS02	8ZB	B	Y150 F151 Y154 G193 E215 A216 K242 V243 E244 E258 M269	Y16 F17 Y20 G59 E81 A82 K108 V109 E110 E124 M135
BS03	LPD	B	L413 Y417	L279 Y283

Gene Ontology

	Molecular Function
GO:0016274	protein-arginine N-methyltransferase activity

	Biological Process
GO:0018216	peptidyl-arginine methylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:5lgp, PDBe:5lgp, PDBj:5lgp
PDBsum	5lgp
PubMed	28330993
UniProt	Q9WVG6\|CARM1_MOUSE Histone-arginine methyltransferase CARM1 (Gene Name=Carm1)

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