Structure of PDB 5lg6 Chain B

Receptor sequence
>5lg6B (length=887) Species: 9823 (Sus scrofa) [Search protein sequence]
LDQSKPWNRYRLPTTLLPDSYNVTLRPYLTPNADGLYIFKGKSIVRFICQ
EPTDVIIIHSKKLNYTMVVLRGVGDSQVPEIDRTELVELTEYLVVHLKGS
LQPGHMYEMESEFQGELADDLAGFYRSEYMEGNVKKVLATTQMQSTDARK
SFPCFDEPAMKATFNITLIHPNNLTALSNMPPKGSSTPLAEDPNWSVTEF
ETTPVMSTYLLAYIVSEFQSVNETAQNGVLIRIWARPNAIAEGHGMYALN
VTGPILNFFANHYNTSYPLPKSDQIALPDFNAGAMENWGLVTYRENALLF
DPQSSSISNKERVVTVIAHELAHQWFGNLVTLAWWNDLWLNEGFASYVEY
LGADHAEPTWNLKDLIVPGDVYRVMAVDALASSHPLTTPAEEVNTPAQIS
EMFDSISYSKGASVIRMLSNFLTEDLFKEGLASYLHAFAYQNTTYLDLWE
HLQKAVDAQTSIRLPDTVRAIMDRWTLQMGFPVITVDTKTGNISQKHFLL
DSSAFDYLWIVPISSIKNGVMQDHYWLRDVSQAQNDLFKTASDDWVLLNV
NVTGYFQVNYDEDNWRMIQHQLQTNLSVIPVINRAQVIYDSFNLATAHMV
PVTLALDNTLFLNGEKEYMPWQAALSSLSYFSLMFDRSEVYGPMKKYLRK
QVEPLFQHFETLTKNWTERPENLMDQYSEINAISTACSNGLPQCENLAKT
LFDQWMSDPENNPIHPNLRSTIYCNAIAQGGQDQWDFAWGQLQQAQLVNE
ADKLRSALACSNEVWLLNRYLGYTLNPDLIRKQDATSTINSIASNVIGQP
LAWDFVQSNWKKLFQDYSFSNLIQGVTRRFSSEFELQQLEQFKKNNMDVG
FGSGTRALEQALEKTKANIKWVKENKEVVLNWFIEHS
3D structure
PDB5lg6 Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
ChainB
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E350 H383 E384 H387 E406 S464 Y472
Catalytic site (residue number reindexed from 1) E286 H319 E320 H323 E342 S400 Y408
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B H383 H387 E406 H319 H323 E342
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0001525 angiogenesis
GO:0006508 proteolysis
GO:0030154 cell differentiation
GO:0043171 peptide catabolic process
GO:0046718 symbiont entry into host cell
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lg6, PDBe:5lg6, PDBj:5lg6
PDBsum5lg6
PubMed28393915
UniProtP15145|AMPN_PIG Aminopeptidase N (Gene Name=ANPEP)

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