Structure of PDB 5ld8 Chain B

Receptor sequence
>5ld8B (length=413) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PSTANGGFPSVVVTAVTATTSISPDIESTWKGLLAGESGIHALEDEFVTK
WDLAVKIGGHLKDPVDSHMGRLDMRRMSYVQRMGKLLGGQLWESAGSPEV
DPDRFAVVVGTGLGGAERIVESYDLMNAGGPRKVSPLAVQMIMPNGAAAV
IGLQLGARAGVMTPVSACSSGSEAIAHAWRQIVMGDADVAVCGGVEGPIE
ALPIAAFSMMRAMSTRNDEPERASRPFDKDRDGFVFGEAGALMLIETEEH
AKARGAKPLARLLGAGITSDAFHMVAPAADGVRAGRAMTRSLELAGLSPA
DIDHVNAHGTATPIGDAAEANAIRVAGCDQAAVYAPKSALGHSIGAVGAL
ESVLTVLTLRDGVIPPTLNYETPDPEIDLDVVAGEPRYGDYRYAVNNSFG
FGGHNVALAFGRY
3D structure
PDB5ld8 Identification of KasA as the cellular target of an anti-tubercular scaffold.
ChainB
Resolution2.13 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C171 H311 E322 K340 H345 F402 F404
Catalytic site (residue number reindexed from 1) C168 H308 E319 K337 H342 F399 F401
Enzyme Commision number 2.3.1.293: meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6U5 B E120 E199 G200 P201 P206 F239 E117 E196 G197 P198 P203 F236 MOAD: Kd=9nM
PDBbind-CN: -logKd/Ki=8.05,Kd=9nM
Gene Ontology
Molecular Function
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0042802 identical protein binding
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0019367 fatty acid elongation, saturated fatty acid
GO:0030497 fatty acid elongation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009274 peptidoglycan-based cell wall

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ld8, PDBe:5ld8, PDBj:5ld8
PDBsum5ld8
PubMed27581223
UniProtP9WQD9|KASA_MYCTU 3-oxoacyl-[acyl-carrier-protein] synthase 1 (Gene Name=kasA)

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