Structure of PDB 5lc0 Chain B

Receptor sequence
>5lc0B (length=190) Species: 64320 (Zika virus) [Search protein sequence]
MVDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLETTDGVYRVMT
RGLLGSTQVGVGVMQEGVFHTMWHVTKGSALRSGEGRLDPYWGDVKQDLV
SYCGPWKLDAAWDGHSEVQLLAVPPGERARNIQTLPGIFKTKDGDIGAVA
LDYPAGTSGSPILDKCGRVIGLYGNGVVIKNGSYVSAITQ
3D structure
PDB5lc0 Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.
ChainB
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6T8 B H1051 K1054 H74 K77 PDBbind-CN: -logKd/Ki=6.70,IC50=0.20uM
BS02 6T8 B S81 G82 D83 V1036 H1051 Y1130 A1132 G1133 S1135 G1151 N1152 V1154 Y1161 S34 G35 D36 V59 H74 Y153 A155 G156 S158 G174 N175 V177 Y184 PDBbind-CN: -logKd/Ki=6.70,IC50=0.20uM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
GO:0044423 virion component

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:5lc0, PDBe:5lc0, PDBj:5lc0
PDBsum5lc0
PubMed27386922
UniProtA0A140DLX4

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