Structure of PDB 5lba Chain B

Receptor sequence
>5lbaB (length=434) Species: 9606 (Homo sapiens) [Search protein sequence]
DPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKSL
CYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQERK
ELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEAH
CVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHLK
KPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQLSGCGIVY
CRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEKVPVIVA
TISFGDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYSRNDR
DQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHAAIAK
YFGDALPACAKGCDHCQNPTAVRRRLEALERSSS
3D structure
PDB5lba Crystal structure of human RECQL5 helicase in complex with 3D fragment (1-cyclohexyl-3-(oxolan-2-ylmethyl)urea)
ChainB
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C411 C427 C431 C434 C393 C409 C413 C416
BS02 ADP B F26 S28 K30 Q34 T54 G55 G57 K58 S59 F16 S18 K20 Q24 T44 G45 G47 K48 S49
BS03 6SV B A193 T194 A195 Y344 Q345 F420 A183 T184 A185 Y326 Q327 F402
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5lba, PDBe:5lba, PDBj:5lba
PDBsum5lba
PubMed
UniProtO94762|RECQ5_HUMAN ATP-dependent DNA helicase Q5 (Gene Name=RECQL5)

[Back to BioLiP]