Structure of PDB 5lb3 Chain B

Receptor sequence
>5lb3B (length=439) Species: 9606 (Homo sapiens) [Search protein sequence]
SDPERRVRSTLKKVFGFDSFKTPLQESATMAVVKGNKDVFVCMPTGAGKS
LCYQLPALLAKGITIVVSPLIALIQDQVDHLLTLKVRVSSLNSKLSAQER
KELLADLEREKPQTKILYITPEMAASSSFQPTLNSLVSRHLLSYLVVDEA
HCVSQWGHDFRPDYLRLGALRSRLGHAPCVALTATATPQVQEDVFAALHL
KKPVAIFKTPCFRANLFYDVQFKELISDPYGNLKDFCLKALGQEADKGLS
GCGIVYCRTREACEQLAIELSCRGVNAKAYHAGLKASERTLVQNDWMEEK
VPVIVATISDKANVRFVAHWNIAKSMAGYYQESGRAGRDGKPSWCRLYYS
RNDRDQVSFLIRKEVAKLQEKRGNKASDKATIMAFDALVTFCEELGCRHA
AIAKYFGDALPACAKGCDHCQNPTAVRRRLEALERSSSW
3D structure
PDB5lb3 Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5.
ChainB
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B C411 C427 C431 C434 C397 C413 C417 C420
BS02 ADP B F26 S28 F29 K30 Q34 T54 G55 G57 K58 S59 F17 S19 F20 K21 Q25 T45 G46 G48 K49 S50
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination

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Molecular Function
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Biological Process
External links
PDB RCSB:5lb3, PDBe:5lb3, PDBj:5lb3
PDBsum5lb3
PubMed28100692
UniProtO94762|RECQ5_HUMAN ATP-dependent DNA helicase Q5 (Gene Name=RECQL5)

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