Structure of PDB 5l3q Chain B

Receptor sequence
>5l3qB (length=307) Species: 9606 (Homo sapiens) [Search protein sequence]
SLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTV
TSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGK
STNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKH
GGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPL
MTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRL
IDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAV
VAALMKA
3D structure
PDB5l3q Structural Basis for Conserved Regulation and Adaptation of the Signal Recognition Particle Targeting Complex.
ChainB
Resolution3.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP B N427 R458 N96 R127
BS02 AMP B F457 L531 F126 L200
BS03 GNP B N427 G428 G430 K431 S432 T433 R458 K589 D591 G615 G617 Q618 N96 G97 G99 K100 S101 T102 R127 K258 D260 G284 G286 Q287
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005047 signal recognition particle binding
GO:0005525 GTP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0006886 intracellular protein transport
GO:0045047 protein targeting to ER
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005785 signal recognition particle receptor complex
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5l3q, PDBe:5l3q, PDBj:5l3q
PDBsum5l3q
PubMed27241309
UniProtP08240|SRPRA_HUMAN Signal recognition particle receptor subunit alpha (Gene Name=SRPRA)

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