Structure of PDB 5l0b Chain B

Receptor sequence
>5l0bB (length=781) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWE
CTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEI
KVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYM
RPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNH
RWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPS
VYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCV
NVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSK
YDPKTIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRW
HVARKPLCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYN
VMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQS
EFDLGCTCDDKSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMP
LWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYG
FLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERN
GVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFT
QPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRD
IEHLTGLDFYRKTSRSYSEILTLKTYLHTYE
3D structure
PDB5l0b Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design.
ChainB
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.39: alkylglycerophosphoethanolamine phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN B S224 G255 S173 G204
BS02 MAN B E223 S224 N436 E172 S173 N385
BS03 6ZM B L213 F273 F274 W275 Y306 L162 F222 F223 W224 Y255 MOAD: ic50=520nM
BS04 ZN B D311 H315 H474 D260 H264 H414
BS05 ZN B D171 T209 D358 H359 D120 T158 D307 H308
BS06 ZN B D739 N741 D743 L745 D661 N663 D665 L667
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0005044 scavenger receptor activity
GO:0016787 hydrolase activity
GO:0030247 polysaccharide binding
GO:0046872 metal ion binding
Biological Process
GO:0006955 immune response

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Molecular Function
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Biological Process
External links
PDB RCSB:5l0b, PDBe:5l0b, PDBj:5l0b
PDBsum5l0b
PubMed27660691
UniProtQ64610|ENPP2_RAT Autotaxin (Gene Name=Enpp2)

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