Structure of PDB 5kwa Chain B

Receptor sequence
>5kwaB (length=454) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PPSGYGVLLATHDDDTVDVFTSGRKMRLTCSPNIDAASLKKGQTVRLNEA
LTVVEAGTFEAVGEISTLREILADGHRALVVGHADEERVVWLADPLIPRK
LRPGDSLLVDTKAGYAFERIPKAEVEDLVLEEVPDVSYADIGGLSRQIEQ
IRDAVELPFLHKELYREYSLRPPKGVLLYGPPGCGKTLIAKAVANSLAKK
MAKSYFLNIKGPELLNGETERHIRLIFQRAREKASEGTPVIVFFDEMDSI
FVVPQLLSEIDGVEGLENVIVIGASNREDMIDPAILRPGRLDVKIKIERP
DAEAAQDIYSKYLTEFLPVHADDLAEFDGDRSACIKAMIEKVVDRMYAEI
DDNRFLEVTYANGDKEVMYFKDFNSGAMIQNVVDRAKKNAIKSVLETGQP
GLRIQHLLDSIVDEFAENEDLPNTTNPDDWARISGKKGERIVYIRTLASR
AIDT
3D structure
PDB5kwa Mycobacterium tuberculosis proteasomal ATPase Mpa has a beta-grasp domain that hinders docking with the proteasome core protease
ChainB
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B G255 P295 G296 C297 G298 K299 T300 L301 I448 Y452 G516 A517 G142 P182 G183 C184 G185 K186 T187 L188 I308 Y312 G376 A377
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0010498 proteasomal protein catabolic process
GO:0019941 modification-dependent protein catabolic process
Cellular Component
GO:0000502 proteasome complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kwa, PDBe:5kwa, PDBj:5kwa
PDBsum5kwa
PubMed28419599
UniProtP9WQN5|ARC_MYCTU Proteasome-associated ATPase (Gene Name=mpa)

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