Structure of PDB 5kv9 Chain B

Receptor sequence
>5kv9B (length=430) Species: 11216 (Human respirovirus 3) [Search protein sequence]
RITHDVGIKPLNPDDFWRCTSGLPSLMKTPKIRLMPGPGLLAMPTTVDGC
VRTPSLVINDLIYAYTSNLITRGCQDIGKSYQVLQIGIITVNSDLVPDLN
PRISHTFNINDNRKSCSLALLNTDVYQLCSTPKVDERSDYASSGIEDIVL
DIVNHDGSISTTRFKNNNISFDQPYAALYPSVGPGIYYKGKIIFLGYGGL
EHPINENAICNTTGCPGKTQRDCNQASHSPWFSDRRMVNSIIVVDKNSIP
KLKVWTISMRQNYWGSEGRLLLLGNKIYIYTRSTSWHSKLQLGIIDITDY
SDIRIKWTWHNVLSRPGNNECPWGHSCPDGCITGVYTDAYPLNPTGSIVS
SVILDSQKSRVNPVITYSTATERVNELAIRNKTLSAGYTTTSCITHYNKG
YCFHIVEINHKSLDTFQPMLFKTEIPKSCS
3D structure
PDB5kv9 The impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B D279 S282 G284 A316 D139 S142 G144 A176
BS02 I57 B R192 I210 D216 K254 E276 Y319 Y337 E409 R424 R502 Y530 R52 I70 D76 K114 E136 Y179 Y197 E267 R282 R360 Y388 MOAD: ic50=1.4uM
PDBbind-CN: -logKd/Ki=5.85,IC50=1.4uM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
GO:0046789 host cell surface receptor binding
Biological Process
GO:0019058 viral life cycle
Cellular Component
GO:0019031 viral envelope

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kv9, PDBe:5kv9, PDBj:5kv9
PDBsum5kv9
PubMed28674426
UniProtG8G134

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