Structure of PDB 5knn Chain B

Receptor sequence
>5knnB (length=450) Species: 9606 (Homo sapiens) [Search protein sequence]
TLTASEIRQRFIDFFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIF
LNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGS
WSFGDYFKELACKMALELLTQEFGIPIERLYVTYFGGDEAAGLEADLECK
QIWQNLGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHL
VNQDDPNVLEIWNLVFIQYNREADGILKPLPKKSIDTGMGLERLVSVLQN
KMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHAR
TITVALADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVV
VQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDS
KTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQ
3D structure
PDB5knn Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair.
ChainB
Resolution2.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.7: alanine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A5A B R77 D84 H94 H95 F98 M100 W176 E213 I214 N216 V218 D239 G241 R246 R74 D81 H91 H92 F95 M97 W173 E210 I211 N213 V215 D236 G238 R243
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004813 alanine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006419 alanyl-tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5knn, PDBe:5knn, PDBj:5knn
PDBsum5knn
PubMed27622773
UniProtP49588|SYAC_HUMAN Alanine--tRNA ligase, cytoplasmic (Gene Name=AARS1)

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