Structure of PDB 5knj Chain B

Receptor sequence
>5knjB (length=259) Species: 9606 (Homo sapiens) [Search protein sequence]
QIKEIKKEQLSGSPWILLRENEVSTLYKGEYHRAPVAIKVFKKLQAGSIA
IVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSIVMEYCELGTL
RELLDREKDLTLGKRMVLVLGAARGLYRLHHSEAPELHGKIRSSNFLVTQ
GYQVKLAGDRVKSTAYLSPQELEDVFYQYDVKSEIYSFGIVLWEIATGDI
PFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVD
EILKKLSTF
3D structure
PDB5knj ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis.
ChainB
Resolution2.88 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K331 S335 N336 G349
Catalytic site (residue number reindexed from 1) K140 S144 N145 G158
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6UX B L209 A228 M254 L263 M283 Y285 C286 G289 E293 L320 A348 G349 L18 A37 M63 L72 M92 Y94 C95 G98 E102 L129 A157 G158 BindingDB: Kd=9300nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5knj, PDBe:5knj, PDBj:5knj
PDBsum5knj
PubMed27832137
UniProtQ8NB16|MLKL_HUMAN Mixed lineage kinase domain-like protein (Gene Name=MLKL)

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