Structure of PDB 5kkr Chain B

Receptor sequence
>5kkrB (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
SQTSIFLQEWDIPFEQLEIGELIGFGQVYHGRWHGEVAIRLIDIERDNED
QLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVR
DAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVIT
DFGLFSISGVLQDKLRIQNGWLCHLAPEIIRQLSPDDKLPFSKHSDVFAL
GTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFC
WAFEQEERPTFTKLMDMLEKLP
3D structure
PDB5kkr Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.
ChainB
Resolution3.509 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D786 K790 N791 D803 Q825
Catalytic site (residue number reindexed from 1) D134 K138 N139 D151 Q168
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6U7 B V680 A690 R692 F725 T739 L741 C742 F793 T802 D803 F804 V28 A38 R40 F73 T87 L89 C90 F141 T150 D151 F152 PDBbind-CN: -logKd/Ki=6.92,IC50=120nM
BindingDB: IC50=120nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5kkr, PDBe:5kkr, PDBj:5kkr
PDBsum5kkr
PubMed27556948
UniProtQ6VAB6|KSR2_HUMAN Kinase suppressor of Ras 2 (Gene Name=KSR2)

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