Structure of PDB 5khw Chain B

Receptor sequence
>5khwB (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
PTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKHIADL
KKEIEILRNLYHENIVKYKGICTENGIKLIMEFLPSGSLKEYLPKNKNKI
NLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLT
KAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELL
TYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVY
QLMRKCWEFQPSNRTSFQNLIEGFEALL
3D structure
PDB5khw Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.
ChainB
Resolution2.47 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1003 A1005 R1007 N1008 D1021 D1040
Catalytic site (residue number reindexed from 1) D128 A130 R132 N133 D146 D165
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP B L881 G882 V889 A906 K908 M956 E957 F958 L959 E966 R1007 L1010 D1021 L15 G16 V23 A40 K42 M81 E82 F83 L84 E91 R132 L135 D146
BS02 MG B N1008 D1021 N133 D146
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5khw, PDBe:5khw, PDBj:5khw
PDBsum5khw
PubMed27827355
UniProtP23458|JAK1_HUMAN Tyrosine-protein kinase JAK1 (Gene Name=JAK1)

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