Structure of PDB 5kd9 Chain B

Receptor sequence
>5kd9B (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSH
IRHMSNKGMEHLYSVPLSDLLLEMLDAH
3D structure
PDB5kd9 Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainB
Resolution1.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E542 M543 I54 K58 L68 V72 E223 M224
BS02 OBT B M343 L346 T347 E353 L387 M421 I424 G521 L525 L544 M39 L42 T43 E49 L83 M117 I120 G208 L212 L225 MOAD: ic50=0.93uM
External links
PDB RCSB:5kd9, PDBe:5kd9, PDBj:5kd9
PDBsum5kd9
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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