Structure of PDB 5kcw Chain B

Receptor sequence
>5kcwB (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYPLSDLLLEMLDAHR
3D structure
PDB5kcw Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainB
Resolution1.905 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 Q375 V376 E380 E542 I54 K58 L68 Q71 V72 E76 E218
BS02 OB9 B M343 T347 E353 F404 M421 G521 M39 T43 E49 F100 M114 G205 MOAD: ic50=0.19uM
BS03 OB9 B M343 T347 E353 M388 F404 M421 G521 L525 M39 T43 E49 M84 F100 M114 G205 L209 MOAD: ic50=0.19uM
External links
PDB RCSB:5kcw, PDBe:5kcw, PDBj:5kcw
PDBsum5kcw
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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