Structure of PDB 5kcu Chain B

Receptor sequence
>5kcuB (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSPLSDLLLEMLD
3D structure
PDB5kcu Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainB
Resolution2.03 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 E542 M543 I54 K58 L68 V72 E224 M225
BS02 OB8 B T347 E353 L387 V418 M421 I424 G521 H524 T43 E49 L83 V114 M117 I120 G210 H213 MOAD: ic50=6.49uM
External links
PDB RCSB:5kcu, PDBe:5kcu, PDBj:5kcu
PDBsum5kcu
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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