Structure of PDB 5kcj Chain B

Receptor sequence
>5kcjB (length=280) Species: 9606 (Homo sapiens) [Search protein sequence]
TRLKIVTIHQEPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPG
SPRHTVPQCCYGFCIDLLIKLARTMNFTYEVHLVADGKFGTQERVNKKEW
NGMMGELLSGQADMIVAPLTINNERAQYIEFSKPFKYQGLTILVKKGTRI
TGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELSTMYRHMEKHNYESA
AEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGFGIGMRK
DSPWKQNVSLSILKSHENGFMEDLDKTWVR
3D structure
PDB5kcj Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
ChainB
Resolution2.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLY B F93 L126 T127 R132 S180 S181 D225 F89 L119 T120 R125 S173 S174 D218
BS02 6RM B I128 P141 Y144 H273 I121 P134 Y137 H266
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5kcj, PDBe:5kcj, PDBj:5kcj
PDBsum5kcj
PubMed26875626
UniProtQ05586|NMDZ1_HUMAN Glutamate receptor ionotropic, NMDA 1 (Gene Name=GRIN1)

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