Structure of PDB 5kcf Chain B

Receptor sequence
>5kcfB (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYT
FLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHI
RHMSNKGMEHLYSPLSDLLLEMLDAHR
3D structure
PDB5kcf Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainB
Resolution2.07 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 V376 L379 D538 L539 E542 M543 I54 K58 L68 V72 L75 D217 L218 E221 M222
BS02 OB4 B M343 T347 E353 L391 F404 M421 I424 G521 L525 L544 M39 T43 E49 L87 F100 M111 I114 G207 L211 L223 MOAD: ic50=0.72uM
External links
PDB RCSB:5kcf, PDBe:5kcf, PDBj:5kcf
PDBsum5kcf
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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