Structure of PDB 5kce Chain B

Receptor sequence
>5kceB (length=239) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRL
AQLLLILSHIRHMSNKGMEHLYSMKPLSDLLLEMLDAHR
3D structure
PDB5kce Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainB
Resolution1.847 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 V376 E380 L539 E542 I54 V72 E76 L230 E233
BS02 OB3 B M343 T347 E353 L387 F404 G420 M421 I424 G521 H524 M39 T43 E49 L83 F100 G116 M117 I120 G217 H220 MOAD: ic50=0.45uM
External links
PDB RCSB:5kce, PDBe:5kce, PDBj:5kce
PDBsum5kce
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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