Structure of PDB 5kcd Chain B

Receptor sequence
>5kcdB (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYFSEASMMGLLTNLADRELVHMIN
WAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLL
LDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSEEK
DHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGM
EHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5kcd Full antagonism of the estrogen receptor without a prototypical ligand side chain.
ChainB
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B I358 K362 L372 Q375 V376 E380 D538 L539 E542 I49 K53 L63 Q66 V67 E71 D216 L217 E220
BS02 OB2 B M343 E353 L387 L391 F404 M421 I424 G521 H524 L525 M528 M34 E44 L78 L82 F95 M112 I115 G199 H202 L203 M206 MOAD: ic50=0.74uM
External links
PDB RCSB:5kcd, PDBe:5kcd, PDBj:5kcd
PDBsum5kcd
PubMed27870835
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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