Structure of PDB 5kbr Chain B

Receptor sequence
>5kbrB (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
EKLRSIVSVGDPKKKYTRFEKIGTVYTAMDVATGQEVAIKQMNEILVMRE
NKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCR
ECLQALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDSKRSEMVGTPYWMA
PEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTP
ELQNPEKLSAIFRDFLNRCLDMDVEKRGSAKELLQHQFLKIAKPLSSLTP
LIAAAKEATK
3D structure
PDB5kbr Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors.
ChainB
Resolution2.36 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N389 K391 D393 N394 D407 T427
Catalytic site (residue number reindexed from 1) N118 K120 D122 N123 D136 T145
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IPW B V284 A297 K299 M344 E345 Y346 L347 G350 L396 V25 A38 K40 M73 E74 Y75 L76 G79 L125 MOAD: ic50=260nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5kbr, PDBe:5kbr, PDBj:5kbr
PDBsum5kbr
PubMed27994749
UniProtQ13153|PAK1_HUMAN Serine/threonine-protein kinase PAK 1 (Gene Name=PAK1)

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