Structure of PDB 5kb6 Chain B

Receptor sequence
>5kb6B (length=343) Species: 10090 (Mus musculus) [Search protein sequence]
ALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDEL
VKKFKVEYHAGGSTQNSMKVAQWLIQEPHKAATFFGCIGIDKFGEILKRK
AADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDL
ERNWVLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFI
SQFFKEALMDVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKAQALP
KVNSKRQRTVIFTQGRDDTIVAAENDVTAFPVLDQNQEEIIDTNGAGDAF
VGGFLSQLVSDKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
3D structure
PDB5kb6 High-resolution structure of the adenosine kinase from Mus musculus in complex with adenosine
ChainB
Resolution1.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R148 G313 A314 G315 D316
Catalytic site (residue number reindexed from 1) R130 G295 A296 G297 D298
Enzyme Commision number 2.7.1.20: adenosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADN B T281 G283 R284 Q305 I308 A343 T263 G265 R266 Q287 I290 A325
Gene Ontology
Molecular Function
GO:0004001 adenosine kinase activity
GO:0004136 deoxyadenosine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006175 dATP biosynthetic process
GO:0006753 nucleoside phosphate metabolic process
GO:0016310 phosphorylation
GO:0032263 GMP salvage
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0044209 AMP salvage
GO:0106383 dAMP salvage
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5kb6, PDBe:5kb6, PDBj:5kb6
PDBsum5kb6
PubMed
UniProtP55264|ADK_MOUSE Adenosine kinase (Gene Name=Adk)

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