Structure of PDB 5k5s Chain B

Receptor sequence
>5k5sB (length=537) Species: 9606 (Homo sapiens) [Search protein sequence]
PDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNFRGFRWL
QAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKID
SPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQFKSFL
RTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERD
ICIDFSELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIV
RRNITGKIWLASEAWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFL
KKVHPRKSVHNGFAKEFWEETFNCHLRPLCTGDENINSVETPYIDYTHLR
ISYNVYLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLR
HLQFTNNMGEQVTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYA
KKGERLFINEEKILWSGFSREVPFSNCSRDCLAGTRKGIIEGEPTCCFEC
VECPDGEYSDETDASACNKCPDDFWSNENHTSCIAKE
3D structure
PDB5k5s Structural mechanism of ligand activation in human calcium-sensing receptor.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA B E231 D234 E197 D200
BS02 TRP B W70 T145 S147 A168 S169 S170 Y218 E297 A298 W49 T111 S113 A134 S135 S136 Y184 E263 A264
BS03 CA B I81 N82 S84 L87 L88 P89 I60 N61 S63 L66 L67 P68
BS04 CA B P39 T100 A144 T145 P18 T79 A110 T111
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5k5s, PDBe:5k5s, PDBj:5k5s
PDBsum5k5s
PubMed27434672
UniProtP41180|CASR_HUMAN Extracellular calcium-sensing receptor (Gene Name=CASR)

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