Structure of PDB 5jsm Chain B

Receptor sequence
>5jsmB (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
GSEFDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQ
QLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHA
SETKFEMKKLIDIARQTARGMDYLHAKSIIHRDLKSNNIFLHEDNTVKIG
DFGLATEKSRSILWMAPEVIRMNPYSFQSDVYAFGIVLYELMTGQLPYSN
INNRDQIIEMVGRGSLSPDLSKVRSNCPKRMKRLMAECLKKKRDERPSFP
RILAEIEELAREL
3D structure
PDB5jsm Chemically Linked Vemurafenib Inhibitors Promote an Inactive BRAF(V600E) Conformation.
ChainB
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D576 K578 N580 N581 D594 S616
Catalytic site (residue number reindexed from 1) D133 K135 N137 N138 D151 S161
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6NB B I463 V471 A481 K483 L514 F516 T529 Q530 W531 C532 S535 H539 F583 D594 F595 G596 I20 V28 A38 K40 L71 F73 T86 Q87 W88 C89 S92 H96 F140 D151 F152 G153 MOAD: ic50=260nM
PDBbind-CN: -logKd/Ki=6.59,IC50=260nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5jsm, PDBe:5jsm, PDBj:5jsm
PDBsum5jsm
PubMed27571413
UniProtP15056|BRAF_HUMAN Serine/threonine-protein kinase B-raf (Gene Name=BRAF)

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