Structure of PDB 5jmo Chain B

Receptor sequence

>5jmoB (length=471) Species: 9606 (Homo sapiens)

DVYQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVVSILDDGIE
KNHPDLAGNYDPGASFDVNDQDPDPQPRYTQMNDNRHGTRCAGEVAAVAN
NGVCGVGVAYNARIGGVRMLDGEVTDAVEARSLGLNPNHIHIYSASWGPE
DDGKTVDGPARLAEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDG
YTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLR
QKCTESHTGTSASAPLAAGIIALTLEANKNLTWRDMQHLVVQTSKPAHLN
ANDWATNGVGRKVSHSYGYGLLDAGAMVALAQNWTTVAPQRKCIIDILTE
PKDIGKRLEVRKTVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVS
PMGTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVLEIENTSEA
NNYGTLTKFTLVLYGTASGSL

3D structure

• PDB: 5jmo The structure of a furin-antibody complex explains non-competitive inhibition by steric exclusion of substrate conformers.
• Chain: B
• Resolution: 1.998 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S150 D191
• Catalytic site (residue number reindexed from 1): S43 D84
• Enzyme Commision number: 3.4.21.75: furin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	D154 H194 E236 S253 W254 G255 E257 D258 D264 G294 N295 D306 Y308 S368	D47 H87 E129 S146 W147 G148 E150 D151 D157 G187 N188 D199 Y201 S261
BS02	CA	B	D174 D179 D181	D67 D72 D74
BS03	CA	B	D115 D162 V205 N208 V210 G212	D8 D55 V98 N101 V103 G105
BS04	CA	B	D258 D301 E331	D151 D194 E224

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:5jmo, PDBe:5jmo, PDBj:5jmo
• PDBsum: 5jmo
• PubMed: 27670069
• UniProt: P09958|FURIN_HUMAN Furin (Gene Name=FURIN)