Structure of PDB 5jk6 Chain B

Receptor sequence
>5jk6B (length=389) Species: 44689 (Dictyostelium discoideum) [Search protein sequence]
QSYHSSIFFSISKGSDKIGGLLEYLEIIKKHNINITRIESRPSKTEKKDY
DFFLDLEYPTENNKEVEKVIKDLEEKGVKATTLQESSNQTYAPWFPRKIS
DLDLFANKPGASDPVYRERRREIAKIASTYKHGDEIPRIDYTEEEIKTWG
VVYNRLKELFPTNACHQHAYIFPLLEQNCGYSPDNIPQLQDISNFLQECT
GWRIRPVQGLLSARDFLNGLAFRVFHATQYIRHPSVPLYTPEPDCCHELL
GHVPLLADPDFADFSQEIGLASIGASDEDIQLLSTCYWFTVEFGLCKEGD
TIRAYGAGILSSTGEMEHFLTDKAKKLPFNPFDACNTEYPITTFQPLYYV
AESFQKAKEQMRQFADSFKKPFSIRYNPYTQSIEILDNK
3D structure
PDB5jk6 Phenylalanine hydroxylase from dictyostelium - apo form
ChainB
Resolution2.072 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H273 H278 E318 S337
Catalytic site (residue number reindexed from 1) H247 H252 E292 S311
Enzyme Commision number 1.14.16.1: phenylalanine 4-monooxygenase.
1.14.16.4: tryptophan 5-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PIN B N403 Y405 N377 Y379
BS02 PIN B T226 P285 D289 T200 P259 D263
BS03 FE B H273 H278 E318 H247 H252 E292
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004505 phenylalanine 4-monooxygenase activity
GO:0004510 tryptophan 5-monooxygenase activity
GO:0004664 prephenate dehydratase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0034617 tetrahydrobiopterin binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006559 L-phenylalanine catabolic process
GO:0006571 tyrosine biosynthetic process
GO:0009072 aromatic amino acid metabolic process
GO:0009094 L-phenylalanine biosynthetic process
GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine
GO:0019954 asexual reproduction
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5jk6, PDBe:5jk6, PDBj:5jk6
PDBsum5jk6
PubMed
UniProtQ54XS1|PH4H_DICDI Phenylalanine-4-hydroxylase (Gene Name=pah)

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