Structure of PDB 5jhq Chain B

Receptor sequence

>5jhqB (length=461) Species: 9606 (Homo sapiens) [Search protein sequence]

ALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDV
VEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNW
NYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLT
GEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNR
VRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAM
DLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELR
ERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVA
SLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHG
AKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMG
NEAVQQILSES

3D structure

PDB

5jhq Tankyrase-1 Ankyrin Repeats Form an Adaptable Binding Platform for Targets of ADP-Ribose Modification.

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	B	R215 F222 G225 F226 L250 N255 S258 F259 H261 D279 W281 Y283 E288	R34 F41 G44 F45 L69 N74 S77 F78 H80 D98 W100 Y102 E107
BS02	peptide	B	R368 S370 L375 G378 Y379 L403 N408 S411 Y412 H414 D432 F436 E441	R187 S189 L194 G197 Y198 L222 N227 S230 Y231 H233 D251 F255 E260

External links

PDB	RCSB:5jhq, PDBe:5jhq, PDBj:5jhq
PDBsum	5jhq
PubMed	27594684
UniProt	O95271\|TNKS1_HUMAN Poly [ADP-ribose] polymerase tankyrase-1 (Gene Name=TNKS)

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