Structure of PDB 5jej Chain B

Receptor sequence
>5jejB (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
ENPLKRLLVPGEEWEFEVTAFYRGRQVFQQTISCPEGLRLVGSEVGDRTL
PGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGGLALWRAGQWLWAQRLGH
CHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLITFTEGSGR
SPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLE
NTVDLHISNSHPLSLTSDQYKAYLQDLVEGMDF
3D structure
PDB5jej Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
ChainB
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B Y260 H263 C267 R285 H288 H290 K313 G349 E350 S351 Y72 H75 C79 R97 H100 H102 K125 G161 E162 S163
BS02 peptide B R211 V257 Y260 R23 V69 Y72
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5jej, PDBe:5jej, PDBj:5jej
PDBsum5jej
PubMed27302953
UniProtQ14653|IRF3_HUMAN Interferon regulatory factor 3 (Gene Name=IRF3)

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