Structure of PDB 5jch Chain B

Receptor sequence

>5jchB (length=655) Species: 9031 (Gallus gallus)

DLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKAS
EQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEVV
KRYDVIICTAQILENSLLNESVRLSDFSLIIIDQCHHTQKEGVYNNIMRR
YLKEKIKNRKQAKELIPQPQILGLTASPGVGGARSNSKAEEHILKICANL
DACRIMTVKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQDIQK
YCQLYPKSEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYNDALQI
NDTIRMVDAYNHLNNFYKELKRRKTAESDDSKQDETDEFLMRLFHAKKKQ
LKELARKPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSALALYHW
IMDNPKFEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGSINLLI
ATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYALVASSG
SGAVEREDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIVEKQMK
AKRDQRITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYHKRENQT
NVEIICKDCGQVWGNMMVYRGLDLPCLKIRNFVVAFEDTKEIFKKWGELP
IIFPD

3D structure

• PDB: 5jch Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
• Chain: B
• Resolution: 2.95 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	K442 E443 Q568 Q572 H733 T785 N786 R817 M900 H901	K140 E141 Q263 Q267 H422 T474 N475 R506 M580 H581
BS02	rna	B	N357 K358 V359 T406 Q408 K700 T701 R702 G730 S735 T763 T764 V765 K977	N60 K61 V62 T109 Q111 K389 T390 R391 G419 S424 T452 T453 V454 K644
BS03	ZN	B	C881 C884 C936 C939	C561 C564 C606 C609
BS04	ADP	B	T300 R302 Q305 G325 G327 K328 R330	T3 R5 Q8 G28 G30 K31 R33

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:5jch, PDBe:5jch, PDBj:5jch
• PDBsum: 5jch
• PubMed: 27203181
• UniProt: D9N195