Structure of PDB 5jc7 Chain B

Receptor sequence

>5jc7B (length=647) Species: 9031 (Gallus gallus)

DLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKAS
EQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEVV
KRYDVIICTAQILENSLLNESVRLSDFSLIIIDQCHHTQKEGVYNNIMRR
YLKEKIKNRPQPQILGLTASPGVGGARSNSKAEEHILKICANLDACRIMT
VKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQDIQKYCQLYPK
SEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYNDALQINDTIRMV
DAYNHLNNFYKELKRRKTAESPLVSKQDETDEFLMRLFHAKKKQLKELAR
KPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSALALYHWIMDNPK
FEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGSINLLIATTVAE
EGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYALVASSGSGAVER
EDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIVEKQMKAKRDQR
ITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYHKREEIICKDCGQ
VWGNMMVYRGLDLPCLKIRNFVVAFETTKEIFKKWGELPIIFPDFDY

3D structure

• PDB: 5jc7 Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
• Chain: B
• Resolution: 2.75 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	N357 K358 V359 G385 T406 Q408 N412 Q572 K700 T701 R702 G730 S735 Q742 T763 T764 V765 E898 K977	N60 K61 V62 G88 T109 Q111 N115 Q260 K383 T384 R385 G413 S418 Q425 T446 T447 V448 E572 K633
BS02	rna	B	K442 E443 Q568 P569 Q572 H733 T785 R817 K861 M900 H901	K140 E141 Q256 P257 Q260 H416 T468 R500 K544 M574 H575
BS03	ZN	B	C881 C884 C936 C939	C555 C558 C595 C598
BS04	ADP	B	R302 Q305 G325 G327 K328 R330 E369	R5 Q8 G28 G30 K31 R33 E72

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:5jc7, PDBe:5jc7, PDBj:5jc7
• PDBsum: 5jc7
• PubMed: 27203181
• UniProt: D9N195