Structure of PDB 5jc3 Chain B

Receptor sequence

>5jc3B (length=661) Species: 9031 (Gallus gallus)

GDLTLRDYQMEVAKPALNGENIIICLPTGSGKTRVAVYITKDHLDKKRKA
SEQGKVIVLVNKVPLVEQHLRKEFNPFLKHWYQVIGLSGDSELKISFPEV
VKRYDVIICTAQILENSLLNATEESVRLSDFSLIIIDQCHHTQKEGVYNN
IMRRYLKEKIKNRKQAKELIPQPQILGLTASPGVGGARSNSKAEEHILKI
CANLDACRIMTVKEHASQLKNQVKEPFKKTVIADDKRRDPFRERIIEIMQ
DIQKYCQLYPKSEFGSQPYEQWVIREERRAAKEEKRKERVCAEHLKKYND
ALQINDTIRMVDAYNHLNNFYKELKRRKTAESDDDSKQDETDEFLMRLFH
AKKKQLKELARKPEYDNEKLMKLRNTLMEEFTKTEEPRGIIFTKTRQSAL
ALYHWIMDNPKFEEVGIKAHFLIGAGHNSETKPMTQNEQREVIDKFRGGS
INLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYAL
VASSGSGAVEREDVNIFRENMMYKAIRRVQEMPPEEYLNKIQDFQLQSIV
EKQMKAKRDQRITFLCKNCHKLICSGEDIQVIENMHHVSVKKDFQHLYHK
RENYQTNVEIICKDCGQVWGNMMVYRGLDLPCLKIRNFVVAFEDTKEIFK
KWGELPIIFPD

3D structure

• PDB: 5jc3 Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
• Chain: B
• Resolution: 2.6 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	B	K442 E443 Q568 Q572 H733 T785 N786 K861 M900	K144 E145 Q267 Q271 H427 T479 N480 K555 M585
BS02	rna	B	N357 K358 V359 G385 T406 Q408 E571 K700 R702 G730 S735 E736 T763 T764 V765 K977	N61 K62 V63 G89 T110 Q112 E270 K394 R396 G424 S429 E430 T457 T458 V459 K650
BS03	ADP	B	R302 Q305 T324 G325 G327 K328 R330 E369 R798	R6 Q9 T28 G29 G31 K32 R34 E73 R492
BS04	ZN	B	C881 C884 C936 C939	C566 C569 C612 C615

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:5jc3, PDBe:5jc3, PDBj:5jc3
• PDBsum: 5jc3
• PubMed: 27203181
• UniProt: D9N195