Structure of PDB 5j5a Chain B

Receptor sequence
>5j5aB (length=523) Species: 185431 (Trypanosoma brucei brucei TREU927) [Search protein sequence]
GPGSMKVEKVFFVTSPIYYVNAAPHIGHVYSTLITDVIGRYHRVKGERVF
ALTGTDEHGQKVAEAAKQKQVSPYDFTTAVAGEFKKCFEQMDYSIDYFIR
TTNEQHKAVVKELWTKLEQKGDIYLGRYEGWYSISDEFLTPQNKVSLESG
HVVTWVSEENYMFRLSAFRERLLEWYHANPGCIVPEFRRREVIRAVEKGL
PDLSVSRARATLHNWAIPVPGNPDHCVYVWLDALTNYLTGSRLRVDESGK
EVSLVDDFNELERFPADVHVIGKDILKFHAIYWPAFLLSAGLPLPKKIVA
HGWWTKDRKKISKSLGNVFDPVEKAEEFGYDALKYFLLRESGFSDDGDYS
DKNMIARLNGELADTLGNLVMRCTSAKINVNGEWPSPAAYTEEDESLIQL
IKDLPGTADHYYLIPDIQKAIIAVFDVLRAINAYVTDMAPWKLVKTDPER
LRTVLYITLEGVRVTTLLLSPILPRKSVVIFDMLGVPEVHRKGIENFEFG
AVPPGTRLGPAVEGEVLFSKRST
3D structure
PDB5j5a Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
ChainB
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H256 H259 S364 D367 S390 S393 K554 K557
Catalytic site (residue number reindexed from 1) H25 H28 S133 D136 S146 S149 K310 K313
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 756 B I248 Y250 D287 H289 G290 V473 Y481 F522 H523 I17 Y19 D56 H58 G59 V229 Y237 F278 H279
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5j5a, PDBe:5j5a, PDBj:5j5a
PDBsum5j5a
PubMed27788467
UniProtQ38C91

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