Structure of PDB 5j42 Chain B

Receptor sequence
>5j42B (length=249) Species: 10090 (Mus musculus) [Search protein sequence]
STISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYL
KKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCV
NVSLGGNEFCLMTSHLESTRGHSAERIRQLKTVLGKMQEAPDSTTVIFAG
DTNLRDREVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAC
KLRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
3D structure
PDB5j42 Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.
ChainB
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6FV B R241 R276 W307 C321 L323 R120 R155 W186 C200 L202 BindingDB: IC50=>1.11e+5nM
BS02 MN B D132 E162 D11 E41
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5j42, PDBe:5j42, PDBj:5j42
PDBsum5j42
PubMed27099339
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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