Structure of PDB 5iz8 Chain B

Receptor sequence
>5iz8B (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
HHHHHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPA
VCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRR
YAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLR
NLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHC
TENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATN
EDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALW
DMSMLKNLIHSKHKMIAMGSAA
3D structure
PDB5iz8 Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
ChainB
Resolution3.06 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide B H427 G487 L488 H28 G88 L89
BS02 peptide B F458 T506 N507 F510 G511 K516 R549 N550 W553 S590 W593 N594 F59 T107 N108 F111 G112 K117 R150 N151 W154 S191 W194 N195
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5iz8, PDBe:5iz8, PDBj:5iz8
PDBsum5iz8
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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