Structure of PDB 5ix1 Chain B

Receptor sequence

>5ix1B (length=419) Species: 10090 (Mus musculus) [Search protein sequence]

GIRLSALCPKFLHTNSTSHTWPFSAVAELIDNAYDPDVNAKQIWIDKTVI
SDHICLTFTDNGNGMTADKLHKMLSFGFSDKVTMNGHVPVGLYGNGFKSG
SMRLGKDAMVFTKNGETMSVGFLSQTYLEVIKAEHVVVPIVTFNKHRQMI
NLTESKASLAAILEHSLFSTEQKLLAELNAIMGKKGTRIIIWNLRSYKNA
TEFDFEKDKYDIRIPEDYKKQERQIAPESDYSLRAYCSILYLKPRMQIII
RGQKVKTQLVSKSLAYIERDVYRPKFLTRTVRITFGFNCRNKDHYGIMMY
HKNRLIKAYEKVGCQLKANNMGVGVVGIIECNFLKPTHNKQDFDYTNEYR
LTILALGEKLNDYWNEMKKRPDQTWVQCDACLKWRKLPDGIDQLPEKWYC
SNNPDPQFRNCEVPEEPED

3D structure

PDB

5ix1 Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin

Chain

Resolution

2.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	B	Y217 Q271 R405 P406 D407 Q408 W410 V411 Q412 W419 D424 E431	Y210 Q253 R370 P371 D372 Q373 W375 V376 Q377 W384 D389 E396
BS02	ZN	B	C413 C416 C435 C446	C378 C381 C400 C411
BS03	ANP	B	N39 V45 M72 M80 S86 K88 G98 L99 Y100 G101 N102 G103 F104 K105 K358	N32 V38 M65 M73 S79 K81 G91 L92 Y93 G94 N95 G96 F97 K98 K340

Gene Ontology

	Molecular Function
GO:0008270	zinc ion binding
GO:0016887	ATP hydrolysis activity

View graph for
Molecular Function

External links

PDB	RCSB:5ix1, PDBe:5ix1, PDBj:5ix1
PDBsum	5ix1
PubMed	27528681
UniProt	F7BJB9\|MORC3_MOUSE MORC family CW-type zinc finger protein 3 (Gene Name=Morc3)

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