Structure of PDB 5ix0 Chain B

Receptor sequence
>5ix0B (length=366) Species: 9606 (Homo sapiens) [Search protein sequence]
KKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHK
ATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFE
FCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVL
AILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGT
GDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVV
LQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNV
ARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEY
MEKIKQRLFENLRMLP
3D structure
PDB5ix0 Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.
ChainB
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.-
3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN B D181 H183 D269 D168 H170 D256
BS02 CA B D179 D181 H183 S202 F203 D166 D168 H170 S189 F190
BS03 CA B F192 T195 V198 Y227 F179 T182 V185 Y214
BS04 6EZ B M35 R39 F114 L144 H145 H146 G154 F155 C156 D181 H183 F210 G305 G306 Y308 M22 R26 F101 L131 H132 H133 G141 F142 C143 D168 H170 F197 G292 G293 Y295 MOAD: Ki=0.519uM
BindingDB: IC50=168nM,Ki=519nM
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity

View graph for
Molecular Function
External links
PDB RCSB:5ix0, PDBe:5ix0, PDBj:5ix0
PDBsum5ix0
PubMed27377864
UniProtQ92769|HDAC2_HUMAN Histone deacetylase 2 (Gene Name=HDAC2)

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