Structure of PDB 5itu Chain B

Receptor sequence
>5ituB (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
PEGPELHLASQFVNEACRALVFGGCVEKSSVSRNPEVPFESSAYRISASA
RGKELRLILSPLPGAQPQQEPLALVFRFGMSGSFQLVPREELPRHAHLRF
YTAPPGPRLALCFVDIRRFGRWDLGGKWQPGRGPCVLQEYQQFRENVLRN
LADKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARSVLEAL
QPDLLELCHSVPKEVVQLAAFRAWLRCYGMPGMSSLQDRHGRTIWFQGDP
GPLAP
3D structure
PDB5itu Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair
ChainB
Resolution2.41 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.-
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B P2 E3 K54 R78 M81 R118 F120 R133 Q168 N176 Y263 R277 T278 P1 E2 K53 R77 M80 R117 F119 R132 Q167 N175 Y228 R242 T243
BS02 dna B R95 H96 I117 R118 R119 F120 R94 H95 I116 R117 R118 F119
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0016829 lyase activity
GO:0019104 DNA N-glycosylase activity
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0006287 base-excision repair, gap-filling
GO:0006979 response to oxidative stress
GO:0032074 negative regulation of nuclease activity
GO:0045008 depyrimidination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5itu, PDBe:5itu, PDBj:5itu
PDBsum5itu
PubMed27354518
UniProtQ96FI4|NEIL1_HUMAN Endonuclease 8-like 1 (Gene Name=NEIL1)

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