Structure of PDB 5is0 Chain B

Receptor sequence
>5is0B (length=394) Species: 10116 (Rattus norvegicus) [Search protein sequence]
TPLALAASSGKIGVLAYILQREIHEPECRHLSRKFTEWAYGPVHSSLYDL
SCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNRLLQDKWDRFVKRIF
YFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEILSVSG
GVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQR
KEYVASMVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVY
LVFLFGFSTAVVTLIEDGKYNSLYSTCLELFKFTIGMGDLEFTENYDFKA
VFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILD
TEKSFLKCMRKAFRSGKLLQVGFTPDGKDDYRWCFRVDEVNWTT
3D structure
PDB5is0 TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
ChainB
Resolution3.43 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6ET B S512 L515 F543 M547 T550 L553 E570 S178 L181 F209 M213 T216 L219 E236 BindingDB: Ki=1300nM,IC50=650nM,EC50=520nM
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5is0, PDBe:5is0, PDBj:5is0
PDBsum5is0
PubMed27281200
UniProtO35433|TRPV1_RAT Transient receptor potential cation channel subfamily V member 1 (Gene Name=Trpv1)

[Back to BioLiP]