Structure of PDB 5iqd Chain B

Receptor sequence
>5iqdB (length=299) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
YDDNATNVKAMKYLIEHYFDNFKVDSIEIIGSGYDSVAYLVNNEYIFKTK
FSTKKGYAKEKAIYNFLNTNLETNVKIPNIEYSYISDELSILGYKEIKGT
FLTPEIYSTMSEEEQNLLKRDIASFLRQMHGLDYTDISECTIDNKQNVLE
EYILLRETIYNDLTDIEKDYIESFMERLNATTVFEGKKCLCHNDFSCNHL
LLDGNNRLTGIIDFGDSGIIDEYCDFIYLLEDSEEEIGTNFGEDILRMYG
NIDIEKAKEYQDIVEEYYPIETIVYGIKNIKQEFIENGRKEIYKRTYKD
3D structure
PDB5iqd Antibiotic Binding Drives Catalytic Activation of Aminoglycoside Kinase APH(2)-Ia.
ChainB
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.7.1.190: aminoglycoside 2''-phosphotransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GNP B S214 I224 K226 Y274 I277 F281 H379 I392 D393 S36 I46 K48 Y94 I97 F101 H199 I212 D213
BS02 RIO B D374 S376 Y408 E411 E415 E416 V444 E445 Y448 E451 D194 S196 Y228 E231 E235 E236 V264 E265 Y268 E271
BS03 MG B H379 D393 H199 D213
External links
PDB RCSB:5iqd, PDBe:5iqd, PDBj:5iqd
PDBsum5iqd
PubMed27161980
UniProtP0A0C1|AACA_STAAU Bifunctional AAC/APH (Gene Name=aacA-aphD)

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