Structure of PDB 5ipf Chain B

Receptor sequence
>5ipfB (length=192) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
ADCVVIEDSFRGFPTEYFCTSPRYDECLDYVLIPNGMIKDRLEKMSMNIV
DYYEACNATSITLMCVLKGGFKFLADLVDGLERTVRARGIVLPMSVEFVR
KDKNVLVVEDIIDTGKTITKLISHLDSLSTKSVKVASLLVKRTSPRNDYR
PDFVGFEVPNRFVVGYALDYNDNFRDLHHICVINEVGQKKFS
3D structure
PDB5ipf In vitro and in vivo characterization of the multiple isoforms of Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferases.
ChainB
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E140 D141 D144 F193 R206
Catalytic site (residue number reindexed from 1) E109 D110 D113 F162 R175
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP B D141 I142 D144 T145 G146 T148 K172 F193 V194 D110 I111 D113 T114 G115 T117 K141 F162 V163
Gene Ontology
Molecular Function
GO:0004422 hypoxanthine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage

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Molecular Function
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Biological Process
External links
PDB RCSB:5ipf, PDBe:5ipf, PDBj:5ipf
PDBsum5ipf
PubMed30772423
UniProtP09383|HPRT_SCHMA Hypoxanthine-guanine phosphoribosyltransferase (Gene Name=HGPRT)

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