Structure of PDB 5inq Chain B

Receptor sequence
>5inqB (length=248) Species: 10090 (Mus musculus) [Search protein sequence]
TISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLK
KRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVN
VSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGD
TNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYK
HRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
3D structure
PDB5inq Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
ChainB
Resolution1.848 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B E162 H236 S239 T240 R241 R276 W307 I317 Y321 E40 H114 S117 T118 R119 R154 W185 I195 Y199
BS02 CA B D132 E162 D10 E40
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5inq, PDBe:5inq, PDBj:5inq
PDBsum5inq
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

[Back to BioLiP]