Structure of PDB 5inp Chain B

Receptor sequence
>5inpB (length=248) Species: 10090 (Mus musculus) [Search protein sequence]
TISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLK
KRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVN
VSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAGD
TNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAYK
HRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
3D structure
PDB5inp Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
ChainB
Resolution1.947 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H236 S239 D272 N274 R276 W307 I317 Y321 H359 H114 S117 D150 N152 R154 W185 I195 Y199 H237
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5inp, PDBe:5inp, PDBj:5inp
PDBsum5inp
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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