Structure of PDB 5inl Chain B

Receptor sequence
>5inlB (length=249) Species: 10090 (Mus musculus) [Search protein sequence]
STISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYL
KKRAASYTIITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCV
NVSLGGNEFCLMTSHLESTREHSAERIRQLKTVLGKMQEAPDSTTVIFAG
DTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCQYTWDTKANNNLRIPAAY
KHRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHWGLLCTLNVVL
3D structure
PDB5inl Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
ChainB
Resolution1.551 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna B H236 S239 T240 R241 D272 N274 R276 W307 I317 Y321 H359 H115 S118 T119 R120 D151 N153 R155 W186 I196 Y200 H238
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5inl, PDBe:5inl, PDBj:5inl
PDBsum5inl
PubMed27060144
UniProtQ9JJX7|TYDP2_MOUSE Tyrosyl-DNA phosphodiesterase 2 (Gene Name=Tdp2)

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