Structure of PDB 5if4 Chain B

Receptor sequence
>5if4B (length=154) Species: 9606 (Homo sapiens) [Search protein sequence]
DDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGV
QRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISF
GAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFH
VEDL
3D structure
PDB5if4 Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
ChainB
Resolution2.392 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6AK B H224 A227 F228 M231 M250 V253 F254 R263 T266 L267 F270 G271 I294 H54 A57 F58 M61 M80 V83 F84 R93 T96 L97 F100 G101 I124 MOAD: Ki<1nM
BindingDB: Ki=<1.000000nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5if4, PDBe:5if4, PDBj:5if4
PDBsum5if4
PubMed27878989
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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