Structure of PDB 5iez Chain B

Receptor sequence
>5iezB (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
ED
3D structure
PDB5iez Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
ChainB
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 6AL B H224 A227 F228 M250 V253 F254 N260 R263 T266 L267 F270 G271 H53 A56 F57 M79 V82 F83 N89 R92 T95 L96 F99 G100 BindingDB: Ki=23nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:5iez, PDBe:5iez, PDBj:5iez
PDBsum5iez
PubMed27878989
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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